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Peptide Targeted Lipid Nanoparticles for Anticancer Drug Delivery

Peptide Targeted Lipid Nanoparticles for Anticancer Drug Delivery

We published a review on peptide nanoparticles that target cancer. We got a Front cover feature with this article. Abstract: Encapsulating anticancer drugs in nanoparticles has proven to be an effective mechanism to alter the pharmacokinetic and pharmacodynamic profiles of the drugs, leading to clinically useful cancer therapeutics like Doxil and DaunoXome. Underdeveloped tumor vasculature and lymphatics allow these first-generation nanoparticles to passively accumulate within the tumor, but work to create the next-generation nanoparticles that actively participate in the tumor targeting process is underway. Lipid nanoparticles functionalized with targeting peptides are among the most often studied. The goal of this article is to review the recently published literature of targeted nanoparticles to highlight successful designs that improved in vivo tumor therapy, and to discuss the current challenges of designing these nanoparticles for effective in vivo performance. ----- visit: http://onlinelibrary.wiley.com/doi/10.1002/adma.201290171/abstract

Keywords: Nanoparticles, Drug Delivery Systems, targeted therapy, targeted therapies, gene delivery, Pharmaceutical Preparations, Nanotechnology, Peptides, Liposomes

Posted by: Kamlesh Shroff

Posted on: 27 Jul 2013

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