Towards a New 3Rs Era in Experimental Research

Christopher R. Cederroth, Marta L. Alves Da Silva, Annemarie Lang, Armand Mensen, Peter Bollen, Benjamin Victor Ineichen, Doris Wilflingseder, Jenny Stina-Maria Sandström, Serban Morosan

Frontiers Media SA

With the persisting need of animal experimentation for fundamental and applied research, the...

Science Behavioral Neuroscience Emotion Regulation and Processing

Keywords: 3R,­Reduce,­Replace,­Refine,­Behavior,­handling,­procedures,­guidelines,­Analgesia,­Anesthesia,­Pain,­stress,­3D organoid,­Human induced-pluripotent stem cells,­Co-cultures,­in vitro,­in vivo,­ex vivo,­Monitoring

Plant-Rhizobia Symbiosis and Nitrogen Fixation in Legumes

Senjuti Sinharoy, Jesus Montiel, Chang Fu Tian

Frontiers Media SA

The reciprocal exchange of chemical signals between legume and rhizobium leads to the establishment...

Science Plant Science Plant Symbiotic Interactions

Keywords: Rhizobia,­Rhizobium,­Nitrogen,­Nitrogen Fixation,­legume

Addictive behaviors among youth and adolescents in the digital age

Lu Yu, Shan Jiang, Tsunetsugu Munakata

Frontiers Media SA

Health Psychiatry Addictive Disorders

Keywords: Youth and adolescents,­Digital age,­behavioral addiction,­Internet addiction,­smartphone addiction disorders,­Internet gambling,­cybersex

Ecological consequences of climate change in boreal marginal seas

Agneta Andersson, Jacob Carstensen, Anke Kremp

Frontiers Media SA

Science Marine Science Global Change and the Future Ocean

Keywords: boreal marginal seas,­Marginal Seas,­Climate Change,­ecology change,­Boreal ecology

Identifying and addressing the impact of exposure to maltreatment and experience in children and child serving systems of care

Melissa Kimber, Wynne Morgan, Jeanette Scheid

Frontiers Media SA

Health Public Health Public Mental Health

Keywords: child maltreatment,­Systems of care,­Child Welfare,­Juvenile justice,­Mental Health

Evolutionary Trajectories in Plant-Associated Pseudomonas and Xanthomonas Strains

Marco Scortichini, Dawn Arnold, Olivier Pruvost, Marie-Agnès Jacques, Adriana J. Bernal

Frontiers Media SA

The strict relationships between bacteria and plants represents one of the major facets of...

Science Plant Science Plant Pathogen Interactions

Keywords: Plant-bacteria interactions,­Virulence,­microbial ecology,­Population Biology,­Epidemiology

Understanding Convergent Evasion Mechanisms in Cancer and Chronic Infection: Implications for Immunotherapy

Hakim Echchannaoui, Matthieu Perreau, Matthias Theobald, Hansjörg Schild

Frontiers Media SA

The complex interactions between the innate and adaptive immune systems function to recognize and...

Health Immunology Cancer Immunity and Immunotherapy

Dynamics at Surfaces: Understanding Energy Dissipation and Physicochemical Processes at the Atomic and Molecular Level

Marco Sacchi, Helen Chadwick, Barbara A. J. Lechner, Glauco Bauerfeldt, Anton Tamtögl

Frontiers Media SA

Energy release to solid interfaces following chemical reactions is ubiquitous in a vast range of...

Science Chemistry Chemical Physics and Physical Chemistry

Keywords: Surface dynamics,­surface diffusion,­Friction,­Surface scattering,­energy dissipation,­Nanostructures,­Quantum Materials,­2D materials

New Strategies for Reversing Cancer Therapy Resistance

Yue Du, Shengxi Chen, Xiujun Liu, Lulu Wang

Frontiers Media SA

Amazing anticancer therapy advancements have been made in the last decade due to tremendous...

Science Pharmacology Pharmacology of Anti-Cancer Drugs

Keywords: Drug Resistance,­cancer therapy,­Mechanism,­Reverse strategy,­Novel drug