Delivering Nucleic Acids to Immune and Non-Immune Cells

Francesca Re, Kirill Afonin, Diana Boraschi

Frontiers Media SA

The possibility of inducing or suppressing the expression of specific genes with the targeted...

Health Immunology Molecular Innate Immunity

Transcriptional regulation of macrophage function

Marten A. Hoeksema, Zsolt Czimmerer, Andreas Patsalos

Frontiers Media SA

Health Immunology Molecular Innate Immunity

Keywords: transcription,­enhancers,­Transcription Factors,­Epigenetic regulation,­Chromatin remodeling,­Signaling Pathways,­Cytokines,­environment,­Genetics,­Disease,­macrophage

Current Challenges in Complement Diagnostics

Erik J.M. Toonen, Per Nilsson, Lillemor Skattum

Frontiers Media SA

The complement system is an important innate immune surveillance network that has a key role in...

Health Immunology Molecular Innate Immunity

Keywords: complement diagnostics,­complement system,­assessment of complement components,­Diagnostic Techniques and Procedures,­Complement-mediated diseases

TNFRSF Agonists: Mode of action and therapeutic opportunities

Nataša Obermajer, Harald Wajant, Adam Zwolak

Frontiers Media SA

The receptors of the TNFRSF (TNFRs) are of overwhelming importance in the regulation of the immune...

Health Immunology Molecular Innate Immunity

Keywords: TNFRSF agonists,­Apoptosis,­Cell Death,­TNFRSF,­4-1BB,­CD27,­DR5/TRAILR2,­EDAR,­Fn14,­OX40,­TNFR2 anti-tumor immunity,­Immunotherapy,­Co-stimulation

Effects of cell interactions at the endothelium in leukocyte differentiation and polarization during inflammation

Alain Haziot, Dan Jane-wit, Efstathios G. Stamatiades

Frontiers Media SA

A complex exchange of signals between endothelial cells and tissues occurs during steady-state and...

Health Immunology Molecular Innate Immunity

Keywords: Cell interactions,­Endothelium,­monocyte,­Lymphocytes,­inflamation

Advances in Mast Cell Physiology and Mast Cell-Driven Diseases

Carlo Pucillo, Ulrich Blank

Frontiers Media SA

Mast cells (MCs) are tissue-resident, innate immune cells with heterogenous phenotypes imprinted by...

Health Immunology Molecular Innate Immunity

Keywords: Immunity,­innate immunity,­Adaptive Immunity,­IgE,­allergy,­mast cell,­Inflammation,­Histmaine,­MC,­Mast cell driven disease,­autoimmune disease,­Cancer

Novel aspects of the immunological and structural barrier of the epidermis

Danuta Gutowska-Owsiak, John Common, Ryan O’Shaughnessy

Frontiers Media SA

Health Immunology Molecular Innate Immunity

Keywords: keratinocyte,­Epidermal barrier,­innate immunity,­Adaptive Immunity,­Immune factors,­keratinocyte differentiation

Innate Immunity: Platelets and their Interaction with other Cellular Elements in Host Defense and Disease Pathogenesis

Meganathan Kannan, Firdos Ahmad, Esaki M. Shankar

Frontiers Media SA

Health Immunology Multiple Sclerosis and Neuroimmunology

Keywords: innate immunity,­platelets,­cell-cell interactions,­Platelet microparticles,­Activated platelets,­Mechanism of action of platelets,­Host defense,­inflammatory responses,­Autoimmune Diseases,­viral infections,­Bacterial Infections

The Fundamental Biology of Basophils in Health and Disease

Christophe Pellefigues, Hajime Karasuyama

Frontiers Media SA

Health Immunology Molecular Innate Immunity