Vector-based Cancer Immunotherapy

Björn L. Frendéus, Yaohe Wang, Ine Lentacker, Monika Semmrich

Frontiers Media SA

Immunotherapy is a clinically proven concept to prevent and treat diverse diseases. Therapeutic...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Vector,­cancer immunotherapy,­Anti tumour,­T cell,­mRNA vectors

Implications of Immune Landscape in Tumor Microenvironment

Selvarangan Ponnazhagan, Juana Serrano Lopez, Somchai Chutipongtanate

Frontiers Media SA

Tumor microenvironment (TME) plays an important role in immunosuppressive mechanisms that result in...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Tumor-immune,­stromal landscape,­Spatial transcriptomics,­Epigenetic mechanisms regulating immune suppression,­extracellular vesicles,­Immune checkpoint blockade,­Next generation tools

Women in Cancer Immunity and Immunotherapy

Adriana Albini, Min Yao, Evelyn Ullrich

Frontiers Media SA

Women in Cancer Immunity and Immunotherapy,

We are delighted to present the inaugural...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Immunity,­Immunotherapy,­immunology,­Inflammation,­Cancer,­Infections,­Vaccines,­Women

Immune Responses Against Tumors - From the Bench to the Bedside

Tiezheng Hou, Xiaoxiao Liu, Chunjing Wang, Keqiang Chen

Frontiers Media SA

Traditionally, surgery, radiotherapy, chemotherapy and hormonal therapy have been used in clinical...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: amino acid metabolism,­machine learning,­Clonal neoantigen,­adoptive cell therapy,­Targeted nanoparticle

Novel Biomarkers in Tumor Immunity and Immunotherapy

Takaji Matsutani, Esra Akbay, Eyad Elkord

Frontiers Media SA

Immune checkpoint inhibitors (ICIs) such as anti-PD-1 and anti-PD-L1 antibodies are highly...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Immunotherapy,­targeted therapy,­Tumor Microenvironment,­immune checkpoint inhibitors,­Cancer biomarkers,­Anti-PD-L1 antibodies

Challenges Associated with Identifying Preclinical Animal Models for the Development of Immune-based Therapies

Rajan P. Adhikari, Rajat Varma, Silke Paust, An Coosemans

Frontiers Media SA

There hasn’t been a better time to be a drug developer for immune-based therapies than the past...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Animal Models,­Cancer,­Immune based therapies

Transcriptome and Single-Cell Sequencing Analyses to Classify Immune Subtypes, Uncover Novel Biomarkers, and Assess Immunotherapeutic Responses in Cancer

Hongda Liu, Jie Shen, Zheng Gong, Xianzhou Song, Peixin Dong

Frontiers Media SA

According to the most recent projections of the International Agency for Research on Cancer (IARC),...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: single-cell sequencing,­immune subtype,­Novel biomarker,­mmunotherapeutic Response,­cancer immunotherapy,­Transcriptome

Reactive Oxygen Species (ROS): Key Components in Cancer Immunotherapy

Anwen Shao, Xiang Xue, Dongmei Zhang, Yu-Hang Zhang, Yang Wang

Frontiers Media SA

The class of highly bioactive chemicals known as reactive oxygen species (ROS) has been extensively...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: reactive oxygen species (ROS),­Tumor microenvironment (TME),­Immune checkpoint blockades,­Immunotherapy,­Oxidative Stress

Mathematical Modeling and Computational Predictions in Oncoimmunology

Vladimir A. Kuznetsov, Heiko Enderling, Mark Chaplain

Frontiers Media SA

Cancer is a complex adaptive dynamic system that causes both local and systemic failures in the...

Health Immunology Cancer Immunity and Immunotherapy

Keywords: Oncoimmunology,­mathematical modeling,­Data-driven,­Computational predictions,­Immunotherapy optimization,­Treatment outcomes