Event Abstract

Effect of extracellular stimulation on neurotransmitter release in a ribbon synapse

  • 1 Institute of Analysis and Scientific Computing, Vienna University of Technology, Austria

The chemical synapse is a structure where two neurons connect to each other. This structure permits information transfer from neuron to neuron via neurotransmitter release. Synapses of specialized presynaptic cells in the retina and inner ear, e.g. retinal photoreceptor and bipolar cells or cochlear hair cells, have an extra electron-dense structure in comparison to ordinary synapses called “ribbon”. Ribbon plays a vital role on modulating vesicle release in response to time dependent input signals. In here the input signal is provided by a micro-electrode located 30 micro meter far from the cell that stimulates the cell extracellularly. At firts, a model is presented for neurotransmitter release in ribbon synapse, then the effect of extracellular stimulation is investigated.

Acknowledgements

This work was supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement No 674901 (switchboard).

References

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Keywords: Differential equation, Retinal bipolar cell, Monte Carlo calculation, Random numbers, ribbon synapse, extracellular stimulation, Neurtransmitter release

Conference: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays, Reutlingen, Germany, 4 Jul - 6 Jul, 2018.

Presentation Type: Poster Presentation

Topic: Stimulation strategies

Citation: Bassereh H and Rattay F (2019). Effect of extracellular stimulation on neurotransmitter release in a ribbon synapse
. Conference Abstract: MEA Meeting 2018 | 11th International Meeting on Substrate Integrated Microelectrode Arrays. doi: 10.3389/conf.fncel.2018.38.00021

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Received: 08 May 2018; Published Online: 17 Jan 2019.

* Correspondence: Mr. Hassan Bassereh, Institute of Analysis and Scientific Computing, Vienna University of Technology, Vienna, Austria, Hassanbassereh@gmail.com