About this Research Topic
In this Research Topic, we will summarize the general features, functional regulation, and signaling network of senescent cells in tumor development and highlight their potential as prognostic biomarkers in multiple cancer treatments, including chemotherapy, radiotherapy, and immunotherapy. Moreover, we discuss possible therapeutic strategies for preventing or rejuvenating senescence in tumor-specific cells. Understanding these critical issues may provide novel strategies to enhance cancer immunotherapy.
The aim of this Research Topic is to cover promising, recent, and novel research trends in the regulation of senescent cells and their use as a potential therapeutic strategy for cancer treatment. This Research Topic will focus on the characterization of senescent cells, their role in tumor patients, and their potential use as a therapeutic strategy for cancer treatment.
We especially welcome article submissions and encourage contributors to address the following themes (but are not limited to):
•Senescent cell characterization (phenotyping, pathways, function, regulation…)
•Different types of tumors (solid, AML…)
•Tumor microenvironment (cells, cytokine, interactions)
•Cancer treatments (chemotherapy, radiotherapy, and immunotherapy including CAR T cells)
•Prognostic biomarkers
•Therapeutic strategies for preventing or rejuvenating tumor-specific cells.
The interested manuscripts could be reviews or data experiments.
Keywords: T cells, senescence, aging, cancer, immunotherapy
Important Note: All contributions to this Research Topic must be within the scope of the section and journal to which they are submitted, as defined in their mission statements. Frontiers reserves the right to guide an out-of-scope manuscript to a more suitable section or journal at any stage of peer review.