Synapse systems biology
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Welcome Trust Sanger Institute, United Kingdom
Proteomic studies show that mammalian synapses comprise 1-2000 proteins organised into networks and multiprotein complexes. There is an important need to understand the logic behind the complexity of synapses. Toward this objective we have mapped and integrated protein interactions, phosphorylation, mRNA and protein expression profiles and phenotypic maps based on mutations of the synapse,. These maps show a highly integrated signaling machine in the postsynaptic proteome with an extraordinary number of combinations of functional states. We have recently completed a study on the molecular evolution of synapses and find that an ancestral protosynapse derived from core proteins was embellished during evolution to produce the complexity observed in mammals. This has lead to a general theory on the origins of synapse complexity and its role in species differences and complex behaviors.
Conference:
Neuroinformatics 2008, Stockholm, Sweden, 7 Sep - 9 Sep, 2008.
Presentation Type:
Oral Presentation
Topic:
Workshop
Citation:
Grant
SG
(2008). Synapse systems biology.
Front. Neuroinform.
Conference Abstract:
Neuroinformatics 2008.
doi: 10.3389/conf.neuro.11.2008.01.154
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Received:
28 Jul 2008;
Published Online:
28 Jul 2008.
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Correspondence:
Seth G Grant, Welcome Trust Sanger Institute, Cambridge, United Kingdom, nemoABS01@frontiersin.org