Curent-source density analysis of the spontaneous and cholinergically modulated slow cortical rhythm
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1
Department of Physiology and Neurobiology, Eötvös Loránd University, Hungary
Slow cortical rhythm (SCR) is a rhythmic alteration of active (hypopolarized) and silent (hyperpolarized) epochs in cortical cells. In deep urethane anesthesia, SCR is characterized by the alternation of almost isoelectrical EEG periods and short epochs of activity consisting of waves at different frequencies. Activation pattern of different cortical layers during spontaneous SCR as well as the role of the ascending cholinergic system in the generation and maintenance of the SCR is poorly understood. In the present experiments, spontaneous as well as cholinergically modulated SCR was recorded from urethane-anesthetized rats and subsequent current source density (CSD) analysis was performed. EEG was recorded by a 16-pole vertical electrode array from the somatosensory cortex. Cholinergic drugs were administered topically near to the location of the recording electrode. CSD analysis of spontaneous SCR revealed that the strongest and earliest sink appear in layer III during active states. The muscarinic antagonist atropine had ambiguous effect on the spontaneous SCR while the cholinergic agonist carbachol abolished it. The acetylcholinesterase inhibitor physostigmine did not abolish SCR but decreased the amplitude of the deep negative EEG shifts associated with the active states. These data suggest that cholinergic agonists and/or increased release of the acetylcholine can obstruct the generation and the maintenance of the SCR while muscarinic antagonists do not necessarily have a facilitary role in anesthetized rats.
Conference:
12th Meeting of the Hungarian Neuroscience Society, Budapest, Hungary, 22 Jan - 24 Jan, 2009.
Presentation Type:
Poster Presentation
Topic:
Research on the cerebral cortex and related structures
Citation:
Toth
A and
Detari
L
(2009). Curent-source density analysis of the spontaneous and cholinergically modulated slow cortical rhythm.
Front. Syst. Neurosci.
Conference Abstract:
12th Meeting of the Hungarian Neuroscience Society.
doi: 10.3389/conf.neuro.01.2009.04.230
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Received:
09 Mar 2009;
Published Online:
09 Mar 2009.
*
Correspondence:
Attila Toth, Department of Physiology and Neurobiology, Eötvös Loránd University, Budapest, Hungary, etn@freemail.hu