Analysis of Extracellular Potentials of Hippocampal and Neocortical Spikes Based on sCSD Method
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1
KFKI Research Institute for Particle and Nuclear Physics of the Hungarian Academy of Sciences, Dept. Biophysics, Hungary
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2
Pfizer Inc.,, Global Research & Development, United States
The way how incoming signals generate action potentials is a key question in understanding the computational methods of neurons. Although there are many techniques of examining single cell activity (e.g.: patch-clamp, electrodes, voltage sensitive dyes), but just few of them can be used for getting spatio-temporal information. An appropriate method for this latter is the sCSD analysis, which we used on hippocampal and neocortical extracellular potentials recorded by a 16-channel multielectrode. The sCSD method is based on the inverse solution of the Poisson-equation. The cell-to-electrode distances and the sCSD distributions were estimated by an auto-focus algorithm. On the resulted spatio-temporal current source density distribution images remarkable phenomenons of the spiking neurons can be observed including dendritic backpropagation and the initiation site of the action potential.
Keywords:
Neurophysiology,
Neuroscience
Conference:
13th Conference of the Hungarian Neuroscience Society (MITT), Budapest, Hungary, 20 Jan - 22 Jan, 2011.
Presentation Type:
Abstract
Topic:
Neurophysiology
Citation:
Cserpán
D,
Scott
L,
Kiss
T,
Hajós
M and
Somogyvári
Z
(2011). Analysis of Extracellular Potentials of Hippocampal and Neocortical Spikes Based on sCSD Method.
Front. Neurosci.
Conference Abstract:
13th Conference of the Hungarian Neuroscience Society (MITT).
doi: 10.3389/conf.fnins.2011.84.00107
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Received:
03 Mar 2011;
Published Online:
23 Mar 2011.
*
Correspondence:
Dr. D. Cserpán, KFKI Research Institute for Particle and Nuclear Physics of the Hungarian Academy of Sciences, Dept. Biophysics, Budapest, Hungary, vintyister@gmail.com