Therapeutic role of repetitive transcranial magnetic stimulation in obsessive compulsive disorder: randomized control trail
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1
Assiut University Hospital, Neurology Department, Faculty of Medicine, Egypt
Obsessive compulsive disorder (OCD) is a condition characterized by distressing, irrational, time consuming, obsessive thoughts and compulsive urges. Lack of an efficient medical therapy for OCD led to frustration of both patients and physicians. This may in part be explained by the lack of understanding of the mechanisms underling OCD. The development of transcranial magnetic stimulation has provided new tool to study the cortical excitability in OCD and to use the repetitive stimulation to modulate this cortex to alleviate the symptoms.
The aim of the present work is: Phase 1: to assess the cortical excitability in OCD patients in order to understand more about its pathophysiological mechanisms, Phase 2: we will evaluate the impact of different frequencies of repetitive transcranial magnetic stimulation (rTMS) on OCD patients.
Material and Methods: Patients with OCD (according to DSM IV crieteria) that failed several standard medical treatments will participate in the study. They will be selected consecutively (through the first 3 months) from those attending the department of Psychiatry, Assiut University Hospital, Egypt. All subjects will give written informed consent. The protocol will be approved by the local ethics committee.
Assessment of cortical excitability (resting motor threshold (rMT), cortical silent period (CSP), transcallosal inhibition, intracortical inhibition anf facilitation (ICI and ICF) for each patient compaired with data of normal volunteer's age and sex matched.
Patients with OCD will be randomly classified to one of three groups; 1 Hz, 10Hz, and sham group with total 2000 pulses at 100% resting motor threshold per session on right pre-motor cortex for two weeks. The primary outcome of the treatment protocol will be the patients’ own self rating of their symptoms using the Hamilton questionnaire for depression and anxiety, Yale Brown Obssive Compulsive scale (YBOCS), and Clinical global Impression-severity of illness at 3 and 6 months.
Conference:
2nd NEUROMED Workshop, Fez, Morocco, 10 Jun - 12 Jun, 2010.
Presentation Type:
Poster Presentation
Topic:
Poster session 1: Neurodegenerative diseases
Citation:
Ahmed
MA
(2010). Therapeutic role of repetitive transcranial magnetic stimulation in obsessive compulsive disorder: randomized control trail.
Front. Neurosci.
Conference Abstract:
2nd NEUROMED Workshop.
doi: 10.3389/conf.fnins.2010.12.00004
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Received:
03 Jun 2010;
Published Online:
03 Jun 2010.
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Correspondence:
Mohammad A Ahmed, Assiut University Hospital, Neurology Department, Faculty of Medicine, Assiut, Egypt, abdelrahman2006ss@yahoo.com