Characteristic changes in the slow cortical waves after 6 hour sleep deprivation
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1
Eötvös Loránd University, Department of Physiology and Neurobiology, Hungary
Deep sleep is a homeostatically regulated process: in most species sleep pressure increases as a function of time and intensity of previous wakefulness and decreases in the course of sleep. The best characterized physiological indicator of sleep intensity is the level of electroencephalogram (EEG) delta power. The EEG slow waves during deep sleep originate from alternating periods of activity and silence of the thalamocortical network. Monitoring frequency, amplitude and duration of the cortical slow waves, locating their current sources and sinks in different cortical layers and recording pyramidal cell activity simultaneously, under control conditions and then following sleep deprivation, we could get deeper insight at homeostatically regulated aspects of deep sleep.
Every property of the down states was changed, but downstate frequency showed the most similar changes to the delta power. Correlations between delta power and downstate frequency strengthened significantly after sleep deprivation. Multiunit activity increased, then decreased, and then increased again during EEG slow waves. These changes apparently preceded EEG slow wave peaks. Sleep deprivation was followed by less pronounced MUA activity increase after slow waves. Simultaneously to MUA activity decrease and general field potential hyperpolarization shift, strong sinks appeared in layer II/III and in deep layer VI with corresponding sources located in layer III/IV and in layer V. All the sinks and sources become stronger following sleep deprivation, but their spatial and temporal distribution was only mildly changed.
It seems that sleep drive is manifested by the more intense potency of downstate inducing but not maintaining processes. Current sink and sources underlying cortical slow waves are strengthened when sleep propensity is elevated albeit MUA activity changes before and during slow waves seem mostly independent of the sleep need.
Conference:
IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010.
Presentation Type:
Poster Presentation
Topic:
Cognition and behavior
Citation:
Hajnik
T,
Nagy
B and
Détári
L
(2010). Characteristic changes in the slow cortical waves after 6 hour sleep deprivation.
Front. Neurosci.
Conference Abstract:
IBRO International Workshop 2010.
doi: 10.3389/conf.fnins.2010.10.00149
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Received:
29 Apr 2010;
Published Online:
29 Apr 2010.
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Correspondence:
Tünde Hajnik, Eötvös Loránd University, Department of Physiology and Neurobiology, Budapest, Hungary, tucsok@tucsok.hu