Event Abstract

Effect of fluorokinolone treatment on the peptidergic innervation of the salivary glands

  • 1 University of Debrecen, Hungary
  • 2 Semmelweis University, Hungary

Fluorokinolones (i.e. Peflacine, PEF) are used in the dental and medical therapy. It was demonstrated that chronic treatment on the rats resulted in disturbance in the secretory function of the salivary glands accompanied by the morphological sign of atrophy in the secretory units. The mechanism of this impairment is unknown. Because the peripheral neuropathy was previously described as the toxic side effect of the chronic PEF treatment we proposed that the morphological and functional disorder of salivary glands developed on the basis of a neuronal disorder. Earlier studies described, that the mast cells could release nerve growth factor (NGF), which is important in the surviving of neurons. The lack of NGF results degenerative processes in the peripheral neurons which can change the expression of neuropeptides (i.e. serotonine, SER).

The aim of this study was to determine the number of mast cells and the qualitative and quantitative changes of SER immunoreactive (IR) nerve terminals in the salivary glands after PEF treatment. Adult rats were treated with PEF for 3 and 7 days. For the visualization of mast cell we have used Toluidine blue staining. Immunohistochemical methods were used to detect the SER containing fibers on the salivary glands. After the chronic treatment we could detect the increased number of mast cells which supports the protective role of the NGF. The number of SER IR fibers decreased compared to the control. The changes in the number of IR fibers support our previous results, that local denervation of salivary gland can cause the atrophy of the acini.

This study was supported by DE OEC Mecenatura Grant 02/2005.

Conference: IBRO International Workshop 2010, Pécs, Hungary, 21 Jan - 23 Jan, 2010.

Presentation Type: Poster Presentation

Topic: Disorders of the nervous system

Citation: Bácskai T, Kelentey B, Deák Á, Zelles T, Skopkó B and Matesz K (2010). Effect of fluorokinolone treatment on the peptidergic innervation of the salivary glands. Front. Neurosci. Conference Abstract: IBRO International Workshop 2010. doi: 10.3389/conf.fnins.2010.10.00020

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Received: 16 Apr 2010; Published Online: 16 Apr 2010.

* Correspondence: Tímea Bácskai, University of Debrecen, Debrecen, Hungary, timi.bacskai@gmail.com