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Correlation between c-reactive protein and CD4+ cell count in HIV-infected and HIV/PTB co-infected patients at the university of maiduguri teaching hospital (UMTH), Maiduguri, Nigeria

Abdulrahman Tahir1*, Haruna Yusuph2, Bukar Bakki2 and Yusuf B. Jibrin1
  • 1 Abubakar Tafawa Balewa University Teaching Hospital, Department of Medicine, Nigeria
  • 2 University of Maiduguri Teaching Hospital, Department of Medicine, Nigeria

The objective of this study was to determine the correlation between CRP and CD4+ cell count in HIV-infected patients at the University of Maiduguri Teaching Hospital; and to compare with HIV/PTB co-infected patients as well as HIV-seronegative healthy age- and sex-matched controls.
A hospital-based cross-sectional comparative study was undertaken. One hundred and twenty consecutive HIV-infected patients comprising 60 HIV+ only and 60 HIV/PTB co-infected patients and 60 apparently healthy HIV-seronegative age- and sex-matched controls were recruited.
The Pearson’s product moment correlation coefficients (r) for the correlation between CRP and CD4+ cell count were -0.596 (p=0.000) for HIV+, -0.365 (p=0.004) for HIV/PTB patients and +0.147 (p=0.263) for healthy controls. Whereas, r for the correlation between CRP and HIV-1 viral load were +0.023 (p=0.859) for HIV+ patients and +0.097 (p=0.463) for HIV/PTB patients. The diagnostic usefulness of the CRP measurement as a surrogate for CD4+ cell count showed sensitivity, specificity and positive predictive values of 80.6%, 72.4% and 75.8% for HIV+ patients and 88.9%, 63.6% and 66.7% for the HIV/PTB patients.
This study found a strong linear negative correlation between CRP and CD4+ cell count in HIV-infected patients as well as those with HIV/PTB co-infection. Therefore, serum CRP level of >10mg/L in HIV-infected patients, can be used to predict low CD4+ cell counts in resource-poor locations lacking the facility for measuring CD4+ cells.

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Keywords: C-Reactive Protein, CD4+ cell, HIV, pulmonary TB, HIVPTB co-infection

Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.

Presentation Type: Abstract

Topic: Host-pathogen interactions

Citation: Tahir A, Yusuph H, Bakki B and Jibrin YB (2013). Correlation between c-reactive protein and CD4+ cell count in HIV-infected and HIV/PTB co-infected patients at the university of maiduguri teaching hospital (UMTH), Maiduguri, Nigeria. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.01193

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Received: 22 Jul 2013; Published Online: 22 Aug 2013.

* Correspondence: Dr. Abdulrahman Tahir, Abubakar Tafawa Balewa University Teaching Hospital, Department of Medicine, Bauchi, Nigeria, abdulrahmantahir@yahoo.com