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Whey and Soy protein supplements improves body composition in patients with Crohn`s disease under azathioprine and anti-TNF-α therapy.

Júlia F. Machado1, Vanessa Oya1, Claudio S. Coy2, André M. Morcillo1 and Maria M. Vilela1*
  • 1 University of Campinas, Centro de Investigação em Pediatria-CIPED, Brazil
  • 2 University of Campinas, Coloproctology Unit, Surgery Department, Brazil

Introduction: Cohn’s disease (CD) is a chronic inflammation of the gastrointestinal tract. Obesity is becoming common among CD patients and it is well known that adipose tissue produces pro-inflammatory cytokines creating a favorable environment for disease progression.

Objective: Evaluate the effects of two nutritional supplements on nutritional status and disease’s activity of CD patients.

Methods: A double-blind, randomized clinical trial study was conducted with two groups of patients: one was supplemented with whey protein enriched with TGF-β (WP-TGF-β) and the other was supplemented with soy protein (SP). Bioimpedance analysis, anthropometric measurements, Crohn’s Disease Activity Index (CDAI), and dosages albumin, prealbumin and C-reactive protein (CRP) were performed at the beginning of the intervention and after 8 and 16 weeks. Spearman’s correlation, Student’s t-test, Friedman test and Analysis of Variance were used to analyze data.

Results: Forty-one patients received WP-TGF-β or SP; 29% were overweight or obese. There were no significant differences between the groups before and during the study, but both supplements improved body composition. Triceps skin fold (p< 0.001) and body fat percentage (p=0.001) decreased, whereas mid-arm muscle circumference (p=0.004), corrected arm muscle area (p=0.005) and lean mass percentage (p=0.001) increased. CDAI was positively correlated to CRP levels, and both negatively correlated to albumin and pre-albumin.

Conclusion: These different sources of protein reduced body fat. Although the underlying mechanisms are still unknown, we suggest that these supplements contribute to a reduction the inflammatory cytokine secretion of the adipose tissue, preventing CD relapse.

Acknowledgements

Financial support: FAPESP (processes: 2007/57558-2 and 2011/04750-9), CNPQ.

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Keywords: Crohn´s disease, Body Composition, Whey Protein, Soy Protein, Inflammatory Bowel Diseases

Conference: 15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.

Presentation Type: Abstract

Topic: Translational immunology and immune intervention

Citation: Machado JF, Oya V, Coy CS, Morcillo AM and Vilela MM (2013). Whey and Soy protein supplements improves body composition in patients with Crohn`s disease under azathioprine and anti-TNF-α therapy.. Front. Immunol. Conference Abstract: 15th International Congress of Immunology (ICI). doi: 10.3389/conf.fimmu.2013.02.00752

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Received: 13 Jun 2013; Published Online: 22 Aug 2013.

* Correspondence: Dr. Maria M Vilela, University of Campinas, Centro de Investigação em Pediatria-CIPED, Campinas, SP, 13083-970, Brazil, marluce@fcm.unicamp.br