Resiniferatoxin exhibits anti-inflammatory property by inhibits pro-inflammatory mediators in endotoxin-challenged mice
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1
Universidad de Guadalajara, Centro Universitario de los Lagos, Mexico
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2
Universidad de Guadalajara, Centro Universitario de Ciencias Exactas e Ingenierias, Mexico
Different chemical structural types of natural products exhibit anti-inflammatory activity and are considered to be potential drug candidates against the inflammation-related pathological processes. Vanilloids bind to the transient receptor potential type V1 (TRPV1) channels, nonselective cation ionophores that play an important role in integration of afferent noxious signals generated by inflammatory mediators. Resiniferatoxin (RTX) is an ultrapotent capsaicin analog showed pharmacological effect including anti-inflammatory activity. BALB/c mice were exposed to LPS application (250µg/100g) in order to evaluate the anti-inflammatory activity RTX. Five different groups were used: (i) control group (none stimulus); (ii) LPS; (iii) LPS-dexamethasone; (iv) LPS- RTX (20 µg/kg) and (v) vehicle control. Plasmas samples were collected and stored at -70ºC, 180 min after the last LPS or treatment administration. The ip administration of RTX provided a significant anti-inflammatory effect. 180 min after RTX administration, the pro-inflammatory cytokines (TNF-α and IL-1β) was significantly inhibited (p<0.005). Reduction in the nitric oxide levels was significantly (p<0.001), this results demonstrate the efficacy and therapeutic potential of RTX in inflammatory process and may be promising drug for targeted inhibition inflammatory diseases.
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Keywords:
Resiniferatoxin,
Inflammation,
TRVP1,
Lipopolysaccharides,
Vanilloids
Conference:
15th International Congress of Immunology (ICI), Milan, Italy, 22 Aug - 27 Aug, 2013.
Presentation Type:
Abstract
Topic:
Immune-mediated disease pathogenesis
Citation:
Gutierrez-Coronado
O,
Viveros Paredes
JM,
Miranda Belltran
MD,
Perez Vega
MI,
Soria-Fregozo
C and
Villalobos Gutierrez
PT
(2013). Resiniferatoxin exhibits anti-inflammatory property by inhibits pro-inflammatory mediators in endotoxin-challenged mice.
Front. Immunol.
Conference Abstract:
15th International Congress of Immunology (ICI).
doi: 10.3389/conf.fimmu.2013.02.00458
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Received:
09 Apr 2013;
Published Online:
22 Aug 2013.
*
Correspondence:
Dr. Oscar Gutierrez-Coronado, Universidad de Guadalajara, Centro Universitario de los Lagos, Lagos de Moreno, Jalisco, 47460, Mexico, ogutierrez@culagos.udg.mx